2 DECEMBER 2016 • VOL 354 ISSUE 6316 1077 SCIENCE
1101 & 1131 Pass the protons, please
2 DECEMBER 2016 • VOLUME 354 • ISSUE 6316
1114 From Science and other journals
1117 INNATE IMMUNITY
Intracellular innate immune
surveillance devices in plants and
animals J. D. G. Jones et al.
REVIEW SUMMARY; FOR FULL TEXT:
1118 RNA SPLICING
Crystal structures of a group II intron
lariat primed for reverse splicing
M. Costa et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
1119 ATMOSPHERIC SCIENCE
Global atmospheric particle formation
from CERN CLOUD measurements
E. M. Dunne et al.
1124 TOPOLOGICAL MAT TER
Quantized Faraday and Kerr rotation
and axion electrodynamics of a 3D
topological insulator L. Wu et al.
1128 GALAXY FORMATION
Molecular gas in the halo fuels the
growth of a massive cluster galaxy at
high redshift B. H. C. Emonts et al.
▶ PERSPECTIVE P. 1102; PODCAST
1131 WATER CHEMISTRY
Spectroscopic snapshots of the
proton-transfer mechanism in water
C. T. Wolke et al.
▶ PERSPEC TIVE P. 1101
1136 WORKING MEMORY
Reactivation of latent working
memories with transcranial magnetic
stimulation N. S. Rose et al.
▶ NEWS STORY P. 1089
Selective modulation of cortical state
during spatial attention
T. A. Engel et al.
1144 PAIN RESEARCH
Gliogenic LTP spreads widely in
M. T. Kronschläger et al.
1148 STRUCTURAL BIOLOGY
Zika virus produces noncoding RNAs
using a multi-pseudoknot structure
that confounds a cellular exonuclease
B. M. Akiyama et al.
Depleting dietary valine
mouse hematopoietic stem cell
transplantation Y. Taya et al.
▶ PERSPEC TIVE P. 1103
Self-renewal of a purified Tie2+
hematopoietic stem cell population
relies on mitochondrial clearance
K. Ito et al.
▶ PERSPEC TIVE P. 1103
T CELL EXHAUSTION
1160 Epigenetic stability of exhausted
T cells limits durability of
reinvigoration by PD-1 blockade
K. E. Pauken et al.
1165 The epigenetic landscape of
T cell exhaustion D. R. Sen et al.
▶ PERSPEC TIVE P. 1104
Generation of influenza A viruses as
live but replication-incompetent virus
vaccines L. Si et al.
ON THE COVER
a functional T cell
an exhausted T cell
chronic infection or
cancer, T cells become
exhausted and lose
many of their core functions. This process
involves a fundamental “rewiring” of the
cellular regulation of gene expression.
Thus, exhausted T cells likely represent
a distinct cell lineage. See pages 1104,
1160, and 1165.
Illustration: Valerie Altounian/Science
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1112 NUCLEAR POWER: SERIOUS RISKS
By P. Johnstone et al.
1112 NUCLEAR POWER: DEPLOYMENT SPEED
By A. B. Lovins
By J. Cao et al.
A comprehensive nuclear test ban
By Ernest J. Moniz
1194 WORKING LIFE
Making a difference, differently
By Matthew Tuthill
Science Staff ............................................ 1078
New Products............................................ 1174
Science Careers ........................................ 1176